Wandering Adventure Party

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• UC Irvine researchers and collaborators at the Marine Biological Laboratory have uncovered cells and structures responsible for helping squid skin change from transparent to colored.
• The scientists drew inspiration from squid skin to develop an advanced tunable material for use in camouflage, displays, and thermal management.

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• Nerve cells can be grown from stem cells in Petri dishes, enabling scientists to research diseases. Previously, it was only possible to create a few dozen different types of nerve cell.
• Using a new method, researchers have now managed to produce over 400 different types of nerve cell.
• Cell culture models with cells of this kind are of interest for research into diseases such as Alzheimer’s and Parkinson’s, as well as for testing new drugs in pharmaceutical research.

The National Institutes of Health is responsible for more than 80% of the world’s grant investment in biomedical research. Its funding has sparked countless medical breakthroughs — on cancer, diabetes, strokes — and plays a fundamental role in the development of pharmaceutical drugs.

Scientists compete vigorously for a slice of the more than $30 billion that the agency doles out annually; they can spend years assembling grant applications that stretch thousands of pages in hopes of convincing peer reviewers of the promise of their projects. Only 1 in 5 gets chosen.

The NIH has rarely revoked funding once it has been awarded. Out of the tens of thousands of grants overseen by the institution since 2012, it terminated fewer than five for violations of the agency’s terms and conditions.

Then Donald Trump was reelected.

Since his January inauguration, his administration has terminated more than 1,450 grants, withholding more than $750 million in funds; officials have said they are curbing wasteful spending and “unscientific” research. The Department of Government Efficiency gave the agency direction on what to cut and why, ProPublica has previously found, bypassing the NIH’s established review process.

“The decision to terminate certain grants is part of a deliberate effort to ensure taxpayer dollars prioritize high-impact, urgent science,” said Andrew G. Nixon, the director of communications for the Department of Health and Human Services. He did not respond to questions about the terminated grants or how patients may be impacted, but he said, “Many discontinued projects were duplicative or misaligned with NIH’s core mission. NIH remains focused on supporting rigorous biomedical research that delivers real results — not radical ideology.”

Targeted projects, however, were seeking cures for future pandemics, examining the causes of dementia and trying to prevent HIV transmission.

The mass cancellation of grants in response to political policy shifts has no precedent, former and current NIH officials told ProPublica. It threatens the stability of the institution and the scientific enterprise of the nation at large. Hundreds of current and former NIH staffers published a declaration this week — cosigned by thousands of scientists across the world, including more than 20 Nobel laureates — decrying the politicization of science at the agency and urging its director to reinstate the canceled grants. Many researchers have appealed the terminations, and several lawsuits are underway challenging the cuts.

It has been difficult for scientists and journalists to convey the enormity of what has happened these past few months and what it portends for the years and decades to come. News organizations have chronicled cuts to individual projects and sought to quantify the effects of lost spending on broad fields of study. To gain a deeper understanding of the toll, ProPublica reached out to more than 500 researchers, scientists and investigators whose grants were terminated.

More than 150 responded to share their experiences, which reveal consequences that experts say run counter to scientific logic and even common sense.

They spoke of the tremendous waste generated by an effort intended to save money — years of government-funded research that may never be published, blood samples in danger of spoiling before they can be analyzed.

Work to address disparities in health, once considered so critical to medical advancement that it was mandated by Congress, is now being cut if the administration determines it has any connection to “diversity,” “equity” or “gender ideology.” Caught in this culling were projects to curb stillbirths, child suicides and infant brain damage.

Researchers catalogued many fears — about the questions they won’t get to answer, the cures they will fail to find and the colleagues they will lose to more supportive countries. But most of all, they said they worried about the people who, because of these cuts, will die.

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